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Natasha Allergy Research Foundation: Clinical Trial Update, May 2024

Natasha Allergy Research Foundation: Clinical Trial Update, May 2024

Ashbury is a proud partner of The Natasha Allergy Research Foundation, the UK’s food allergy charity, and supports the Foundation in its mission to Make Allergy History.

With our backing, The Natasha Allergy Research Foundation is funding a pioneering clinical trial that may allow children and young people with food allergies to live without the fear of a potentially fatal reaction.

About the Trial

There are three groups of participants in the trial: children aged 6 to 23 with a peanut allergy, and children aged 3 to 23 with a cow’s milk allergy. Children aged two and three with a peanut allergy have recently been added to the trial.

In total, 275 children and young people with these food allergies will be recruited for the trial.

Once enrolled, each is given a very small amount of food to which they are allergic at a dose that is safe for them, which is taken according to a standardised protocol under medical supervision. This may be given either in a hospital clinic or at home with medical support.

If they tolerate the food, they then take a daily ‘dose’ of this real food at home, and the amount is gradually increased by the medical team roughly every two weeks whilst being closely monitored for any adverse effects.

Latest Results from the Natasha Clinical Trial:

We are delighted to announce that the Natasha Clinical Trial has released its first update. Initial results are promising.

The Natasha Clinical Trial uses daily doses of everyday food products, taken under strict medical supervision, rather than expensive pharmaceuticals to train the bodies of children and young people to tolerate the foods that cause them severe allergic reactions. The four key updates are:

  • So far, a total of 139 children, aged 2 to 23 years with food allergies to peanut or cow’s milk, have started treatment on the Natasha Clinical Trial.
  • Early evidence shows children on the Natasha Trial are tolerating milk and peanuts to which they were previously severely allergic.
  • 9 NHS hospitals are taking part in the Natasha Trial, expanded from the original 5.
  • The Natasha Trial is training a network of NHS staff to offer oral immunotherapy treatment (OIT).

Natasha’s parents Nadim and Tanya Ednan-Laperouse, who have both been awarded OBEs for their services to charity and people with allergies, are delighted with how the trial is progressing.

Tanya said: ‘This is a major first step in our mission to make food allergies history. We look forward to seeing the final results.’

Nadim added: ‘We can’t rely on big pharma and its giant profits to be a game-changer for people living with allergies.

‘That is why we are harnessing the support of the food industry, who have helped fund this trial, to prove that OIT can work with everyday foods, making it more feasible to be available on the NHS.’

Sibel Sonmez-Ajtai, Paediatric Allergy Consultant and Principal Investigator at Sheffield Children’s Hospital, one of the centres involved in the trial, said: ‘This study is enabling us to do something we would never have dreamed of doing before – giving patients the foods we know they are allergic to!

‘This treatment is not a cure for a food allergy, but what it achieves is life transforming. To have a patient who has had anaphylaxis to 4mls of milk to then tolerate 90mls within six to eight months is nothing less than a miracle.’

What Comes Next?

Ashbury’s Culture Club will be driving the way for additional fundraising to support the continued advancement of the trial.

James Post MD at Ashbury said “What an incredible update to receive. NARF’s vision to ‘Make Allergy History’ is inspiring; I am immensely proud to support this project and create real change for those suffering from food allergy. It aligns with the Ashbury core purpose of promoting consumer safety and empowering individuals to make informed food choices.  Congratulations to all involved.”

Caitlin Stewart, Marketing Manager

My background in Food Science and Marketing means I have a unique combination of commercial creativity and technical food manufacturing experience. My ambition is to bring clarity to the complex world of compliance through the simple and eye-catching communication of Ashbury's services.

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